SOLUBLE TWEAK PLASMA LEVELS INCREASE AFTER RENAL TRANSPLANTATION AND ASSOCIATE WITH THE IMPROVEMENT OF ENDOTHELIAL FUNCTION



Description:

Soluble TWEAK (sTWEAK) and asymmetric dimethyl arginine (ADMA) concentrations have been associated with endothelial function in patients with chronic kidney disease (CKD). We tested the hypothesis that the improvement in endothelial function observed after renal transplantation is directly linked to the normalization of both sTWEAK and ADMA.



Instructions:

One-hundred and seventy five kidney transplant recipient (71% men; 31.6±9.4 years) were studied immediately before and on the 180th day post-transplantation. At each visit, blood samples were taken to assess circulating levels of sTWEAK and ADMA. Brachial artery endothelium-dependent vasodilatation (FMD) assessments were also performed.


Project Admins:

  • Mahmut İlker Yılmaz


Project start - end date: 01/01/2012 - 01/01/2016