IL-10 kinetics are different in CKD patients. An earlier study showed inter-individual difference in serum IL-10 levels in patients undergoing hemodialysis due to promoter gene polymorphism. To the best of our knowledge and despite the leading role of CV mortality in CKD, no study has studied the predictive ability of serum IL-10 levels in non-dialysis dependent CKD patients. In this study we aimed to evaluate whether serum IL-10 levels could predict development of CV events in CKD patients. Moreover, we determined the relationship between endothelial dysfunction, the earliest recognizable form of atherosclerosis, and serum IL-10 levels in CKD.