RED CELL DISTRIBUTION WIDTH IS INDEPENDENTLY RELATED TO ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH CHRONIC KIDNEY DISEASE

Description:

Red cell distribution width (RDW) is a measure of red cell size variability and has been shown to be an independent predictor of mortality in different patient populations and in general population. We aimed to evaluate the association of RDW with endothelial dysfunction in patients with various stages of chronic kidney disease (CKD).

Instructions:

This was an observational cohort study with a prospectively maintained cohort. Patients with all stages of CKD (1 to 5) were included in the study. Endothelial function was assessed with flow mediated dilatation (FMD). Estimated glomerular filtration rate (eGFR) was calculated with MDRD equation. Carotid intima media thickness (CIMT) was determined with Doppler ultrasound. Clinical and demographic characteristics, biochemistry values, complete blood counts, ferritin, C-reactive protein, and cholesterol levels were recorded. Spearman correlation was used to determine correlates of RDW. Multivariate linear regression model was used to assess independent associates of FMD in whole cohort.

Project Admins:

Mahmut İlker Yılmaz

Project start - end date: 01/01/2012 - 01/01/2016