MEAN CORPUSCULAR VOLUME INDEPENDENTLY PREDICTS CARDIOVASCULAR MORBIDITY AND MORTALITY IN PATIENTS WITH CHRONIC KIDNEY DISEASE



Description:

Mean corpuscular volume (MCV) is a measure of size of red blood cells. Macrocytosis may or may not be associated with anemia. Recently a few studies showed association of high MCV values (macrocytosis) with all-cause mortality. We aimed to assess the relationship of MCV with cardiovascular (CV) morbidity and mortality in patients with chronic kidney disease (CKD). We also aimed to investigate the effect of MCV on endothelial function assessed by flow mediated dilatation (FMD).



Instructions:

This is an observational cohort study with a prospectively maintained cohort of patients with stage 1-5 CKD. Estimated glomerular filtration rate (eGFR) was calculated with MDRD equation. FMD was measured at baseline. Baseline laboratory values were studied and clinic-demographic characteristics were recorded. Multivariate linear regression and stepwise backward cox regression analyses were used to predict independent associates of FMD and composite CV events, respectively.


Project Admins:

  • Mahmut İlker Yılmaz


Project start - end date: 01/01/2013 - 01/01/2015